WebOct 5, 2024 · To explore the function of CDK12 in the kidney, we generated a novel CDK12 flox/flox line harboring loxP sites flanking exon 4 of the Cdk12 gene. By breeding with cdh16-Cre transgene mice, in which Cre expression is limited to the renal tubules, including Bowman’s capsule, proximal tubule, loop of Henle, distal tubule, and the collecting duct, … WebPkd1 fl/fl; Cdh16-Cre mice were generated by crossing Pkd1 fl/fl mice with Cdh16-Cre mice. Pkd1 fl/fl; Cdh16-Cre mice were then crossed with A-CREB transgenic mice. Both sexes were used in the kidney-specific mouse model, and mice were euthanized at P7. Five pairs of kidneys were collected for tissue section analysis and the rest were used for ...
Tg (Cdh16-cre/ERT2)F427Djmp Transgene Detail MGI Mouse …
WebJul 1, 2014 · Epithelial specific knockout of Invs in Invs flox/flox;Cdh16-Cre mutant mice resulted in renal cyst formation and severe stromal fibrosis, while Invs flox/flox;Foxd1-Cre mice, where Invs is deleted in stromal cells, displayed no observable phenotypes up to the young adult stage, highlighting a significant role of epithelial-stromal crosstalk. WebJun 22, 2024 · Cdh16, also known as kidney specific protein (Ksp), is expressed in kidney distal nephrons including the loop of Henle, distal convoluted tubules, and collecting … dining room table with rotating center
Cell Division: Turning cell cycle entry on its head eLife
WebJun 22, 2024 · Cdh16-cre mice (012237, B6.Cg-Tg(Cdh16 -cre)91Igr/J) were purchased from the Jackson Lab, which express Cre recombinase under the control of the mouse cadherin 16 (Cdh16) promoter, and the Cre ... WebMar 1, 2024 · Cdh16 (Cadherin16, or Ksp-cadherin) is strongly expressed in epithelia of nephron tubules and collecting ducts in rabbit, mouse and human. Transgenic mice with … WebMar 1, 2024 · The model (Cdh16 Cre::Tfeb fs) was obtained by crossing the Tfeb conditional overexpressing mouse line carrying Tfeb-3xFlag fs/fs under the control of the chicken … fortnite hide in snow