WebJun 12, 2024 · Again, this will depend on the medication you take, the dose that you take, and how your body handles medication. The drug I take, Zoloft (sertraline), has a half-life of 26 hours. This means that when I take my dose in the morning, it will take my body 26 hours to eliminate half that dose; and then it takes another 26 hours to eliminate half ... WebNov 29, 2024 · Suddenly stopping your antidepressant: If you've been taking an antidepressant for a month or more and you suddenly quit taking it, you're far more likely to have discontinuation symptoms than if you had tapered off slowly. 1 It may take one to four days before you notice symptoms.
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